Concomitant hypofibrinogenemia and factor XI deficiency as rare cause of bleeding during urgent dentistry: case report and short review of the literature

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Published Jun 29, 2023
DOI: https://doi.org/10.22551/2023.39.1002.10253
Christoph Sucker Christof Geisen Jens Litmathe Ursula Schmitt

Abstract

Hypofibrinogenemia and Factor XI deficiency are rare defects of hemostasis, potentially leading to spontaneous bleeding manifestations and increased bleeding risk during surgery, dentistry, and interventions. Due to the different mode of inheritance, the concomitance of both defects is extremely rare and the clinical management of combined hypofibrinogenemia and factor XI deficiency is not standardized. Here, we report a rare case of concomitant genetically determined hypofibrinogenemia and factor XI deficiency as a cause of increased spontaneous bleeding and bleeding complications during dentistry. The diagnostic procedure including screening assays, single clotting factor determinations, genetic analyses, and also use of thrombin generation assays (TGA) are described. Also, we present our considerations regarding the development of an adequate prophylaxis of bleeding with fibrinogen concentrate in this case. The literature regarding the issue is briefly discussed.

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Keywords

hypofibrinogenemia, factor XI deficiency, bleeding, dentistry

References
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How to Cite
Sucker, C., Geisen, C., Litmathe, J., & Schmitt, U. (2023). Concomitant hypofibrinogenemia and factor XI deficiency as rare cause of bleeding during urgent dentistry: case report and short review of the literature. Archive of Clinical Cases, 10(2), Arch Clin Cases. 2023;10(2):110-113. https://doi.org/10.22551/2023.39.1002.10253
Issue
Vol. 10 No. 2 (2023)
Section
Case Reports

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How to Cite

Sucker, C., Geisen, C., Litmathe, J., & Schmitt, U. (2023). Concomitant hypofibrinogenemia and factor XI deficiency as rare cause of bleeding during urgent dentistry: case report and short review of the literature. Archive of Clinical Cases, 10(2), Arch Clin Cases. 2023;10(2):110-113. https://doi.org/10.22551/2023.39.1002.10253