Prenatal diagnosis of an adrenal mature teratoma mimicking a neuroblastoma

Camille Garcia, Giulia Fusi, Marion Gambart, Agnes Sartor, Anne Gomez-Mascard, Olivier Abbo


Teratomas are defined by the presence of cell types from different germ layers, they typically involve the gonads or the sacrococcygeal region and are rarely retroperitoneal. Prenatally detected adrenal teratomas are extremely uncommon. Aim of this paper is to share our experience with an adrenal antenatal mass initially diagnosed as a left adrenal neuroblastoma that turned out to be a mature teratoma after microscopical examination. We present the case of a male fetus with antenatal diagnosis of a left adrenal cystic image at the 22nd weeks of amenorrhea. The fetal magnetic resonance imaging showed a non-calcified cystic mass of the left adrenal gland, compatible with a neuroblastoma. At birth an ultrasound confirmed the presence of an anechogenic lesion of the left adrenal gland. The infant was closely monitored during his first year and in the absence of significant regression of the adrenal mass, it was decided to perform a laparoscopic left adrenalectomy. Unexpectedly, the final pathological diagnosis was mature cystic adrenal teratoma. In conclusion, an adrenal mass diagnosed antenatally is generally a hemorrhage or a neuroblastoma. Adrenal teratomas are very rare and those diagnosed antenatally even more. At present, we have no clinical, biological, or radiological evidence to suspect them before surgical removal. There are only two other cases of unexpected adrenal teratoma in infants described in Literature.


adrenal mass, mature teratoma, antenatal diagnosis, laparoscopy, children

Full Text:



Castillo OA, Vitagliano G, Villeta M, Arellano L, Santis O. Laparoscopic resection of adrenal teratoma. JSLS. 2006;10(4):522-4. PMID: 17575773; PMCID: PMC3015770.

Lam KY, Lo CY. Teratoma in the region of adrenal gland: a unique entity masquerading as lipomatous adrenal tumor. Surgery. 1999;126(1):90-94. doi: 10.1067/msy.1999.98924. PMID: 10418600.

Gatcombe HG, Assikis V, Kooby D, Johnstone PA. Primary retroperitoneal teratomas: a review of the literature. J Surg Oncol. 2004;86(2):107-113. doi: 10.1002/jso.20043. PMID: 15112254.

Yao W, Li K, Xiao X, Zheng S, Chen L. Neonatal suprarenal mass: differential diagnosis and treatment. J Cancer Res Clin Oncol. 2013;139(2):281-286. doi: 10.1007/s00432-012-1316-x. PMID: 23064785.

Moon SB, Shin HB, Seo JM, Lee SK. Clinical features and surgical outcome of a suprarenal mass detected before birth. Pediatr Surg Int. 2010;26(3):241-246. doi: 10.1007/s00383-009-2531-7. PMID: 19908050.

Li Y, Zhong Z, Zhao X. Primary mature teratoma presenting as an adrenal tumor in a child. Urology. 2011;78(3):689-691. doi: 10.1016/j.urology.2010.12.022. PMID: 21316095.

Vasies I, Brasseur-Daudruy M, Lempicki M, et al. Imagerie des surrénales chez l'enfant. EM Consult. 2015;

Khong PL, Lam KY, Ooi CG, Liu MJ, Metreweli C. Mature teratomas of the adrenal gland: imaging features. Abdom Imaging. 2002;27(3):347-350. doi: 10.1007/s00261-001-0106-8. PMID: 12173369.

Hero B, Simon T, Spitz R, et al. Localized infant neuroblastomas often show spontaneous regression: results of the prospective trials NB95-S and NB97. J Clin Oncol. 2008;26(9):1504-1510. doi: 10.1200/JCO.2007.12.3349. PMID: 18349403.

Society for Maternal-Fetal Medicine (SMFM); Sperling J. Adrenal neuroblastoma. Am J Obstet Gynecol. 2021;225(5):B5-B6. doi: 10.1016/j.ajog.2021.06.037. PMID: 34507794.

Kuo EJ, Sisk AE, Yang Z, et al. Adrenal teratoma: a case series and review of the literature. Endocr Pathol. 2017;28(2):152-158. doi: 10.1007/s12022-017-9468-5. PMID: 28091891.

Oguzkurt P, Ince E, Temiz A, et al. Prenatal diagnosis of a mass in the adrenal region that proved to be a teratoma. J Pediatr Hematol Oncol. 2009;31(5):350-351. doi: 10.1097/MPH.0b013e318190d765. PMID: 19415017.

Haddad SE, Hessissen L, Kababri ME, et al. Primary mature adrenal teratoma in infant. Pan Afr Med J. 2020;37:27. doi: 10.11604/pamj.2020.37.27.24016. PMID: 33062128; PMCID: PMC7532853.


Copyright (c) 2023 Camille Garcia, Giulia Fusi, Marion Gambart, Agnes Sartor, Anne Gomez-Mascard, Olivier Abbo

Creative Commons License
Archive of Clinical Cases is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


ISSN: 2360-6975