Gyanendra Singh Anurag Singh Anuragani Verma Yogendra Verma Neeraj Kumar

Abstract

Aspergillus is a ubiquitous fungus that can cause a variety of clinical syndromes. It can lead to a spectrum of clinical presentations depending upon the severity of the disease, degree of immune compromisation, nature and intensity of inflammatory host response. Ovarian aspergilloma is extremely unusual, only a few case reports have been described in the literature. Here, we report a case of ovarian aspergilloma which was masquerading as ovarian neoplasm on clinical examination and radiology. To the best of our knowledge, this is the first case report of isolated ovarian aspergillosis in an immunocompetent patient.

##plugins.themes.bootstrap3.article.details##

Keywords

Aspergillus, Ovary, Neoplasm, Fungal infection

References
1. Harmouchi H, Sani R, Issoufou I, et al. Pulmonary aspergilloma: from classification to management. Asian Cardiovasc Thorac Ann. 2020;28(1):33-38. doi: 10.1177/0218492319895113. PMID: 31799858.
2. Singh V. Fungal Rhinosinusitis: Unravelling the Disease Spectrum. J Maxillofac Oral Surg. 2019;18(2):164-179. doi: 10.1007/s12663-018-01182-w. PMID: 30996535; PMCID: PMC6441414.
3. Taccone FS, Van den Abeele AM, Bulpa P, et al. Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes. Crit Care. 2015;19(1):7. doi: 10.1186/s13054-014-0722-7. PMID: 25928694; PMCID: PMC4344741.
4. Bongomin F, Gago S, Oladele RO, Denning DW. Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision. J Fungi (Basel). 2017;3(4):57. doi: 10.3390/jof3040057. PMID: 29371573; PMCID: PMC5753159.
5. Kleinschmidt-DeMasters BK. Central nervous system aspergillosis: a 20-year retrospective series. Hum Pathol. 2002;33(1):116-124. doi: 10.1053/hupa.2002.30186. PMID: 11823982.
6. Ho CL, Deruytter MJ. CNS aspergillosis with mycotic aneurysm, cerebral granuloma and infarction. Acta Neurochir (Wien). 2004;146(8):851-856. doi: 10.1007/s00701-004-0292-6. PMID: 15254808.
7. Cumbo-Nacheli G, de Sanctis J. A near fatal case of invasive aspergillosis. Am J Case Rep. 2012;13:169-172. doi: 10.12659/AJCR.883320. PMID: 23569520; PMCID: PMC3615918.
8. Kostelnik FV, Fremount HN. Mycotic tubo-ovarian abscess associated with the intrauterine device. Am J Obstet Gynecol. 1976;125(2):272-274. doi: 10.1016/0002-9378(76)90612-8. PMID: 1266911.
9. Kim SW, Nah MY, Yeum CH, et al. Pelvic aspergillosis with tubo-ovarian abscess in a renal transplant recipient. J Infect. 2001;42(3):215-217. doi: 10.1053/jinf.2001.0791. PMID: 11545558.
10. Cadena J, Thompson GR 3rd, Patterson TF. Invasive Aspergillosis: Current Strategies for Diagnosis and Management. Infect Dis Clin North Am. 2016;30(1):125-142. doi: 10.1016/j.idc.2015.10.015. PMID: 26897064.
11. Gillemain R, Lavarde C, Amrein P, Chevalier A, Glotz D. Invasive aspergillosis after transplantation. Transplant Proc. 1995;27(1):1307–1309.
12. Anila KR, Somanathan T, Mathews A, Jayasree K. Fruiting bodies of Aspergillus: An unusual finding in histopathology. Lung India. 2013;30(4):357-359. doi: 10.4103/0970-2113.120623. PMID: 24339500; PMCID: PMC3841699.
13. Aquino VR, Nagel F, Andreolla HF, et al. The performance of real-time PCR, galactomannan, and fungal culture in the diagnosis of invasive aspergillosis in ventilated patients with chronic obstructive pulmonary disease (COPD). Mycopathologia. 2012;174(2):163-169. doi: 10.1007/s11046-012-9531-1. PMID: 22382738.
14. Henry T, Iwen PC, Hinrichs SH. Identification of Aspergillus species using internal transcribed spacer regions 1 and 2. J Clin Microbiol. 2000;38(4):1510-1515. doi: 10.1128/JCM.38.4.1510-1515.2000. PMID: 10747135; PMCID: PMC86477.
15. Peral-Cagigal B, Redondo-González LM, Verrier-Hernández A. Invasive maxillary sinus aspergillosis: A case report successfully treated with voriconazole and surgical debridement. J Clin Exp Dent. 2014;6(4):e448-451. doi: 10.4317/jced.51571. PMID: 25593673; PMCID: PMC4282918.
How to Cite
Singh, G., Singh, A., Verma, A., Verma, Y., & Kumar, N. (2023). Ovarian aspergilloma in an immunocompetent patient masquerading as ovarian neoplasm. Archive of Clinical Cases, 10(1), Arch Clin Cases 2023; 10(1):39-41. https://doi.org/10.22551/2023.38.1001.10237
Section
Case Reports

How to Cite

Singh, G., Singh, A., Verma, A., Verma, Y., & Kumar, N. (2023). Ovarian aspergilloma in an immunocompetent patient masquerading as ovarian neoplasm. Archive of Clinical Cases, 10(1), Arch Clin Cases 2023; 10(1):39-41. https://doi.org/10.22551/2023.38.1001.10237