Acute meningitis complicated with ventriculitis caused by Streptococcus dysgalactiae subsp. dysgalactiae

Mariana Guerra, Daniela Marado, Jorge Fortuna


Streptococcus dysgalactiae subspecies dysgalactiae (SDSD), also known as Lancefield group C streptococcus, is a pathogen found in animals. It is known to cause pyogenic infections in animals and is one of the most common pathogens that can cause mastitis in cattle. Very few reports of SDSD causing human diseases to have been reported in the literature, but we report a case of community-acquired meningitis and pyogenic ventriculitis caused by SDSD. This report is the first case of SDSD causing a central nervous system (CNS) infection in humans and aims to raise awareness about the role of SDSD in CNS infections. It also seeks to promote the recognition of this bacteria as a potential cause of invasive diseases.


Streptococcus dysgalactiae subspecies dysgalactiae; Acute ventriculitis; Community-acquired meningitis

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Vandamme P, Pot B, Falsen E, Kersters K, Devriese LA. Taxonomic study of lancefield streptococcal groups C, G, and L (Streptococcus dysgalactiae) and proposal of S. dysgalactiae subsp. equisimilis subsp. nov [published correction appears in Int J Syst Bacteriol. 1997;47(2):605]. Int J Syst Bacteriol. 1996;46(3):774-781. doi:10.1099/00207713-46-3-774

Alves-Barroco C, Roma-Rodrigues C, Raposo LR, et al. Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: In vitro and in vivo infection of human cells and zebrafish as biological models. Microbiologyopen. 2019;8(1):e00623. doi: 10.1002/mbo3.623. Epub 2018 Mar 25. PMID: 29577680; PMCID: PMC6341033.

Alves-Barroco C, Caço J, Roma-Rodrigues C, et al. New Insights on Streptococcus dysgalactiae subsp. dysgalactiae Isolates. Front Microbiol. 2021;12:686413. doi:10.3389/fmicb.2021.686413

Nathan B, Pillai V, Ayyan SM, Ss A, Prakash Raju KNJ. Streptococcus dysgalactiae Subspecies dysgalactiae Infection Presenting With Septic Shock. Cureus. 2021; 13(1):e12465. doi: 10.7759/cureus.12465. PMID: 33552782; PMCID: PMC7854318.

Jordal S, Glambek M, Oppegaard O, Kittang BR: New tricks from an old cow: infective endocarditis caused by Streptococcus dysgalactiae subsp. dysgalactiae. J Clin Microbiol. 2015; 53:731-4. 10.1128/JCM.02437-14

Koh TH, Sng LH, Yuen SM, et al. Streptococcal cellulitis following preparation of fresh raw seafood. Zoonoses Public Health. 2009;56(4):206-208. doi:10.1111/j.1863-2378.2008. 01213.x

Park MJ, Eun IS, Jung CY, et al. Streptococcus dysgalactiae subspecies dysgalactiae infection after total knee arthroplasty: a case report. Knee Surg Relat Res. 2012;24(2):120-123. doi:10.5792/ksrr.2012.24.2.120

Im G, Park Y, Kim M, et al. A case of neonatal meningitis caused by Streptococcus dysgalactiae subspecies dysgalactiae and Herpes simplex virus. Pediatr Infect Vaccine. 2019;26:194-198. 10.14776/piv.2019.26. e17

Erdem H, Ozturk-Engin D, Cag Y, et al. Central nervous system infections in the absence of cerebrospinal fluid pleocytosis. Int J Infect Dis. 2017;65:107-109. doi: 10.1016/j.ijid.2017.10.011. PMID: 29081366.

de Vries LS, Volpe J. Bacterial and fungal intracranial infections. In: Volpe's Neurology of the Newborn, 6th Ed., Volpe J, Inder T, Darras B, et al (Eds), Elsevier, Philadelphia 2017. p.1050.

Adhikari P, Antala D, Pyakuryal B, et al. Community-Acquired Meningitis Complicated by Pyogenic Ventriculitis: A Case Report. Cureus. 2022;14(4):e23907. doi: 10.7759/cureus.23907. PMID: 35530893; PMCID: PMC9077952.

Miyairi I, Causey KT, DeVincenzo JP, Buckingham SC. Group B streptococcal ventriculitis: a report of three cases and literature review. Pediatr Neurol. 2006;34(5):395-399. doi: 10.1016/j.pediatrneurol.2005.09.003

Salmon JH. Ventriculitis complicating meningitis. Am J Dis Child. 1972;124(1):35-40. doi:10.1001/archpedi.1972.02110130037005

Adams RD, Kubik CS, Bonner FJ. The clinical and pathological aspects of influenzal meningitis. Arch Pediatr (N Y). 1948;65(8):408-441. PMID: 18883966.

Ziai WC, Lewin JJ 3rd. Update in the diagnosis and management of central nervous system infections. Neurol Clin. 2008;26(2):427-viii. doi: 10.1016/j.ncl.2008.03.013

Gronthoud F, Hassan I, Newton P. Primary pyogenic ventriculitis caused by Neisseria meningitidis: case report and review of the literature. JMM Case Rep. 2017;4(1): e005078. doi:10.1099/jmmcr.0.005078

Brouwer MC, McIntyre P, Prasad K, van de Beek D. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev. 2015;2015(9):CD004405. doi: 10.1002/14651858.CD004405.pub5


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