Abnormal uterine bleeding in a female with Klippel Trenaunay syndrome

Ashiq Pramchand


Klippel-Trenaunay syndrome is a rare syndrome that is defined by capillary, venous, and lymphatic malformations associated with limb overgrowth. The author describes a 33-year-old SARS-CoV-2 positive South African Black Zulu female known with Klippel Trenaunay syndrome in this case report. Her presentation with abnormal uterine bleeding and multiple cystic lymphangiomas has been rarely described in existing literature, which provides further understanding of the gynecological manifestations of this syndrome.


uterine bleeding; Klippel Trenaunay syndrome; SARS-CoV-2 positive

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Nam G, Lee SR, Choi S. Clitoromegaly, Vulvovaginal Hemangioma Mimicking Pelvic Organ Prolapse, and Heavy Menstrual Bleeding: Gynecologic Manifestations of Klippel-Trénaunay Syndrome. Medicina (Kaunas). 2021;57(4).

Cucinella G, Di Buono G, Geraci G, Ricupati F, Gullo G, Maienza E, et al. Uterine Involvement in Klippel-Trenaunay Syndrome: A Rare But Relevant Event. Review of the Literature. Front Surg. 2022;9:893320.

International Society for the Study of Vascular Anomalies©. Classification of vascular anomalies Milwaukee, WI, US: ISSVA; 2014 [cited 2017 abr 18. Available from: http://www.issva.org/classification].

Srividya Naganathan PT. Klippel Trenaunay Weber Syndrome StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [updated July 19 2022; Available from: https://www.ncbi.nlm.nih.gov/books/NBK558989/.

Vahidnezhad H, Youssefian L, Uitto J. Klippel-Trenaunay syndrome belongs to the PIK3CA-related overgrowth spectrum (PROS). Exp Dermatol. 2016;25(1):17-19.

Rodriguez Peña M, Ovando E. [Klippel-Trenaunay-Weber syndrome with vesical and uterine involvement treated by endoscopic and endovascular routes]. Medicina (B Aires). 2020;80(1):84-86.

Milman T, Murji A, Papillon-Smith J. Abnormal Uterine Bleeding in a Patient with Klippel-Trenaunay Syndrome. J Minim Invasive Gynecol. 2019;26(5):791-793.

Jacob AG, Driscoll DJ, Shaughnessy WJ, Stanson AW, Clay RP, Gloviczki P. Klippel-Trénaunay syndrome: spectrum and management. Mayo Clin Proc. 1998;73(1):28-36.

Willman EA, Collins WP, Clayton SG. Studies in the involvement of prostaglandins in uterine symptomatology and pathology. Br J Obstet Gynaecol. 1976;83(5):337-341.

Husmann DA, Rathburn SR, Driscoll DJ. Klippel-Trenaunay Syndrome: Incidence and Treatment of Genitourinary Sequelae. J Urol. 2007;177(4):1244-1249.

Mneimneh S, Tabaja A, Rajab M. Klippel-Trenaunay Syndrome with Extensive Lymphangiomas. Case Rep Pediatr. 2015;2015:581394.

DOI: http://dx.doi.org/10.22551/2022.36.0903.10209

Copyright (c) 2022 Ashiq Pramchand

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ISSN: 2360-6975