Christoph Sucker Alexander Bosch Christian Duecker Claus Schüttler-Janikulla Ursula Schmitt Jens Litmathe

Abstract

Acquired hemophilia is a rare coagulation disorder that is not diagnosed by routine clinical laboratory tests. Thus, many perioperative or acute emergent bleeding complications remain unclear until the underlying cause is specified. We report two cases of postoperative bleeding in the context of dental surgery in which subsequent acquired hemophilia could be confirmed and present a short review from the literature.

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Keywords

bleeding complications, acquired hemophilia, dental surgery

References
1. Sumanth KN, Prashanti E, Aggarwal H, et al. Interventions for treating post-extraction bleeding. Cochrane Database Syst Rev. 2016; 10(6):CD011930.doi:10.1002/14651858.CD011930.pub2. Update in: Cochrane Database Syst Rev. 2018 Mar 04;3:CD011930. PMID: 2728545.
2. Abed H, Ainousa A. Dental management of patients with inherited bleeding disorders: a multidisciplinary approach. Gen Dent. 2017; 65(6):56-60. PMID: 29099367.
3. Sucker C, Schmitt U, Litmathe J. [Acquired inhibitory body hemophilia: A life-threatening reason for the tendency of hematoma-genesis.]. Wien Med Wochenschr. 2021 Aug 2. German. doi: 10.1007/s10354-021-00866-2. PMID: 34338901.
4. Knoebl P, Marco P, Baudo F, et al. EACH2 Registry Contributors. Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). J Thromb Haemost. 2012; 10(4):622-31.
5. Tiede A, Collins P, Knoebl P, et al. International recommendations on the diagnosis and treatment of acquired hemophilia A. Haematologica. 2020; 105(7):1791-1801. doi:10.3324/haematol.2019.230771. Epub 2020 May 7. PMID: 32381574; PMCID: PMC7327664.
6. Tiede A, Wahler S. The rising incidence of acquired haemophilia A in Germany. Haemophilia. 2021; 27(4):e466-e468. doi: 10.1111/hae.14149. PMID: 32937680.
7. Stockschläder M, Ruf L, Linderer A, et al. Induction of tolerance after combined immunosuppression and -adsorption in two patients with acquired haemophilia after severe haemorrhages controlled by sequential administration of rFVIIa and FEIBA. Thromb Haemost. 2009; 101(3):586-590.
8. Hansenne A, Hermans C. Emicizumab in acquired haemophilia A: about two clinical cases and literature review. Ther Adv Hematol. 2021; 12: 20406207211038193. doi:10.1177/20406207211038193.PMID: 34471508; PMCID: PMC8404634.
9. Tiede A, Kemkes-Matthes B, Knöbl P. Should emicizumab be used in patients with acquired hemophilia A? J Thromb Haemost. 2021; 19(3):637-644. doi: 10.1111/jth.15208. PMID: 33306259.
How to Cite
Sucker, C., Bosch, A., Duecker, C., Schüttler-Janikulla, C., Schmitt, U., & Litmathe, J. (2022). Acquired hemophilia as a rare cause of excessive bleeding during dentistry: report of two cases and short review. Archive of Clinical Cases, 9(1), Arch Clin Cases 2022; 9(1):12-18. https://doi.org/10.22551/2022.34.0901.10197
Section
Case Reports

How to Cite

Sucker, C., Bosch, A., Duecker, C., Schüttler-Janikulla, C., Schmitt, U., & Litmathe, J. (2022). Acquired hemophilia as a rare cause of excessive bleeding during dentistry: report of two cases and short review. Archive of Clinical Cases, 9(1), Arch Clin Cases 2022; 9(1):12-18. https://doi.org/10.22551/2022.34.0901.10197