A rare case of Brugada syndrome induced by hyperglycemia

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Published Jul 22, 2021
DOI: https://doi.org/10.22551/2021.31.0802.10181
Brandon W. Knopp Bailey Pierce Vishnu Muppala Jonathan Rosman Jeniel Parmar

Abstract

Brugada syndrome is a rare genetic disorder of the cardiac sodium channels associated with an increased risk of sudden cardiac death.  It is characterized by an electrocardiogram (EKG) showing a right bundle branch block with an elevation in the ST segment. This condition is associated with mutations in several pathologic genes including the most notable mutation in the SCN5A gene, which encodes for a voltage-gated cardiac sodium channel. The Brugada pattern on EKG can be spontaneous but can also be induced by a variety of etiologies including fever, electrolyte abnormalities, increased vagal tone and drugs such as sodium channel blockers, calcium channel blockers, tricyclic antidepressants and alcohol. One uncommon cause of Brugada syndrome is hyperglycemia. Of particular importance in diabetic patients, hyperglycemia can induce chronic cardiovascular complications as well as acute cardiac events via the induction of the Brugada pattern on EKG. We present a case of a 21-year-old non-insulin compliant diabetic man presenting to the Emergency Department with diabetic ketoacidosis (DKA) who exhibits the Brugada pattern EKG prior to developing ventricular tachycardia followed by cardiac arrest. The patients condition was induced by prolonged hyperglycemia in the setting of DKA with relatively mild electrolyte and pH abnormalities. Herein, this case is presented to highlight the Brugada pattern leading to cardiac arrest as a potential consequence of hyperglycemia and inform physicians on its incidence.

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Keywords

Brugada syndrome, sudden cardiac death, hyperglycemia

References
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How to Cite
Knopp, B. W., Pierce, B., Muppala, V., Rosman, J., & Parmar, J. (2021). A rare case of Brugada syndrome induced by hyperglycemia. Archive of Clinical Cases, 8(2), Arch Clin Cases 2021; 8(2):25-30. https://doi.org/10.22551/2021.31.0802.10181
Issue
Vol. 8 No. 2 (2021)
Section
Case Reports

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How to Cite

Knopp, B. W., Pierce, B., Muppala, V., Rosman, J., & Parmar, J. (2021). A rare case of Brugada syndrome induced by hyperglycemia. Archive of Clinical Cases, 8(2), Arch Clin Cases 2021; 8(2):25-30. https://doi.org/10.22551/2021.31.0802.10181