Liver cirrhosis and the anticoagulant treatment – from guided indications to daily practice - case report

Nicoleta Dima, Luminiţa Gina Vâţă, Elena Rezuş, Anca Trifan


This is the case of a 64-year old hypertensive, diabetic patient, known to have liver cirrhosis, with a history of pulmonary thromboembolism, with permanent electrical cardiac stimulation, who was hospitalized for a newly diagnosed giant popliteal hematoma. The patient is currently discharged and following oral anticoagulant treatment.


liver cirrhosis, oral anticoagulant treatment, permanent electrical cardiac stimulation, type 2 diabetes mellitus, pulmonary thromboembolism

Full Text:



Zatonski WA, Sulkowska U, Manczuk M, et al. Liver cirrhosis mortality in Europe, with special attention to Central and Eastern Europe. Eur Addict Res 2010; 16(4):193-201.

Kamath PS, Kim WR, Advanced Liver Disease Study Group. The model for end-stage liver disease (MELD). Hepatology 2007; 45(3):797-805.

Al Ghumlas AK, Abdel Gader AG, Al Faleh FZ. Haemostatic abnormalities in liver disease: could some haemostatic tests be useful as liver function tests? Blood Coagul Fibrinolysis. 2005; 16(5):329-35.

Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. N Engl J Med 2011; 365(2):147-156.

Hickman IJ, Macdonald GA. Impact of diabetes on the severity of liver disease. Am J Med 2007; 120(10):829-834.

Holstein A, Hinze S, Thiessen E, Plaschke A, Egberts EH. Clinical implications of hepatogenous diabetes in liver cirrhosis. J Gastroenterol Hepatol 2002; 17(6):677-681.

Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001; 409(6818):307-312.

Nishida T, Tsuji S, Tsujii M, et al. Oral glucose tolerance test predicts prognosis of patients with liver cirrhosis. Am J Gastroenterol 2006; 101(1):70-75.

Tolman KG, Fonseca V, Dalpiaz A, Tan MH. Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease. Diabetes Care 2007; 30(3):734-743.

El-Serag HB, Everhart JE. Diabetes increases the risk of acute hepatic failure. Gastroenterology 2002; 122(7):1822-1828.

Del Vecchio Blanco C, Gentile S, Marmo R, Carbone L, Coltorti M. Alterations of glucose metabolism in chronic liver disease. Diabetes Res Clin Pract 1990; 8(1):29-36.

Roberts LN, Patel RK, Arya R. Haemostasis and thrombosis in liver disease. Br J Haematol 2010; 148(4):507-521.

Tufano A, Guida A, Di Minno MN, Prisco D, Cerbone AM, Di Minno G.. Prevention of venous thromboembolism in medical patients with thrombocytopenia or with platelet dysfunction: a review of the literature. Semin Thromb Hemost 2011; 37(3):267-74.

Moller S, Henriksen JH. Cirrhotic cadiomyopathy. J Hepatol 2010; 53(1):179-190.


Copyright (c) 2015 Archive of Clinical Cases

Creative Commons License
Archive of Clinical Cases is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


ISSN: 2360-6975