Fatal neonatal persistent pulmonary hypertension caused by vegetations of infective endocarditis – case report and review of the literature

Andreea Luciana Avasiloaiei, Ecaterina Iftime, Daniela Claudia Scripcaru, Andrei Petrariu, Gabriela Ildiko Zonda, Maria Stamatin, Luminița Păduraru


Neonatal infective endocarditis is a rare condition and usually pertains to a specific class of immunologically depressed preterm infants, with a long history of invasive procedures in the Neonatal Intensive Care Unit. We report the case of an aggressive and fatal neonatal infective endocarditis in a full-term infant, who developed massive endocardial vegetations on the tricuspid valve, leading to persistent pulmonary hypertension of the newborn, unresponsive to nitric oxide ventilation. Post-mortem cardiac cultures were positive with Serratia marcescens, an unusual germ for an early-onset infection, which was absent in blood cultures.


neonatal infective endocarditis; persistent pulmonary hypertension of the newborn; endocardial vegetations; Serratia marcescens

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DOI: http://dx.doi.org/10.22551/2020.27.0702.10171

Copyright (c) 2020 Andreea Luciana Avasiloaiei, Ecaterina Iftime, Daniela Claudia Scripcaru, Andrei Petrariu, Gabriela Ildiko Zonda, Maria Stamatin, Luminița Păduraru

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