Granulomatosis with polyangiitis a challenge for diagnosis and treatment - case report

Anca Codreanu, Madalina Ionela Chiriac, Elena Rezus


In this article we report the case of a 46 year-old male presenting with pulmonary, sinusal, otic, nasal and laryngeal lesions. He was diagnosed in December 2013 with granulomatosis with polyangiitis and we tried to achieve remission with cyclophosphamide and glucocorticoids. The onset of the disease included pansinusitis accompanied with mastoiditis and paralysis of the left facial nerve, bilateral hearing loss and episodes of intense headache. The patient underwent two surgeries to solve the Ear-Nose-Throat (ENT) area symptoms which have delayed the diagnosis and the initiation of appropriate therapy.


granulomatosis with polyangiitis, ENT, necrotizing glomerulonephritis, “saddle” nose

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