Necrotizing enterocolitis in a full term infant

Maria Catalina Vaz Ferreira, Mario Moraes


This report details the case of a full-term infant, who developed Necrotizing Enterocolitis (NEC) during the first 24 hours of life. While most cases of NEC occur among patients already admitted to the NICU for a variety of conditions, this case develops in a previously healthy newborn who developed early-onset disease. Our analysis describes the factors predisposing to this condition and discusses the most effective antimicrobial treatment strategies. The focus of the article is to highlight the role of certain risk factors (alterations in the gut microbiome, hypertonic formula feeds, perinatal hypoxia and patent ductus arteriosus with left-to-right shunt) in tipping the scale towards the development of NEC.


necrotizing enterocolitis, full-term, microbiome, breastfeeding

Full Text:



Sharma R, Hudak ML. A clinical perspective of necrotizing enterocolitis: past, present, and future. Clin Perinatol 2013; 40(1):27-51.

Luo LJ, Li X, Yang KD, et al. Broad-spectrum antibiotic plus metronidazole may not prevent the deterioration of necrotizing enterocolitis from stage II to III in full-term and near-term infants: a propensity score-matched cohort study. Medicine 2015; 94(42):e1862.

Neu J. Probiotics and necrotizing enterocolitis. Clin Perinatol 2014; 41(4):967–978.

Ng PC, Chan KY, Poon TC. Biomarkers for prediction and diagnosis of necrotizing enterocolitis. Clin Perinatol 2013; 40(1):149-159.

Marseglia L, Manti S, D’Angelo G, et al. Colonic stenosis post necrotizig enterocolitis in term newborn with acquired Cytomegalovirus infection. Chirurgia 2015; 110(2):175-178.

Short S, Papillon S, Berel D, et al. Late onset of necrotizing enterocolitis in the full term infant is associated with increased mortality: results from a two-center analysis. J Pediatr Surg 2015; 49(6):950-953.

Burjonrappa SC, Schwartzberg D. Chromosomal microarray testing in NEC: a case report. J Neonatal Surg 2016; 5(3):34.

Gritz EC, Bhandari V. The human neonatal gut microbiome: a brief review. Front Pediatr 2015; 3:17.

Elgin TG, Kern SL, McElroy SJ. Development of the neonatal intestinal microbiome and its association with necrotizing enterocolitis. Clin Ther 2016; 38(4):706-715.

Christensen RD1, Lambert DK, Baer VL, Gordon. Necrotizing Enterocolitis in Term Infants. Clin Perinatol 2013; 40(1):69–78.

Huang-Fu CR, Li P, Tian YF. Clinical significance of serum intestinal fatty acid-binding protein in full term infants with necrotizing enterocolitis. Zhongguo Dang Dai Er Ke Za Zhi 2014; 16 (11):1125-1128.

Wang W, Xue L, Ma T, Li Y, Li Z. Non-intervention observation: Dynamic evolution laws of inflammatory response in necrotizing enterocolitis. Exp Ther Med 2016; 12(3):1770-1774.


Copyright (c) 2016 Maria Catalina Vaz Ferreira, Mario Moraes

Creative Commons License
Archive of Clinical Cases is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


ISSN: 2360-6975