Elamein Yousif http://orcid.org/0000-0002-8644-3827 Elamin Dahawi Sarah Premraj http://orcid.org/0000-0003-4852-7752 Wissem Melki


Infection with SARS-CoV-2 has been shown to predispose to thromboembolic events. The risk of such thromboses further increases in those with underlying inherited or acquired prothrombotic states.

The authors present a 30-year-old lady who developed acute abdominal pain, three days after recovery from a mild COVID-19 infection. She was also using oral contraceptive pills. Laboratory investigations revealed elevated inflammatory markers, and a contrast-enhanced abdominal CT scan demonstrated portal vein thrombosis (PVT). Due to the unusual site of thrombosis, a thrombophilia screen was performed, which detected a heterozygous Factor V Leiden mutation (FVL). Thus, her PVT was attributed three simultaneous risk factors, namely COVID-19 infection, OCP use and FVL mutation. She was initiated on anti-coagulation, with which she improved significantly.

In patients presenting with thromboses at uncommon sites, investigation for evidence of recent Covid-19 infection and screening for inherited and acquired thrombophilias should be considered, while discontinuing any offending medications.



SARS-CoV-2, COVID-19, portal vein thrombosis, Factor V Leiden mutation, oral contraceptive

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How to Cite
Yousif, E., Dahawi, E., Premraj, S., & Melki, W. (2024). Triple Whammy in a Patient with Portal Vein Thrombosis. Archive of Clinical Cases, 11(1), 16-18. https://doi.org/10.22551/2024.42.1101.10280
Case Reports

How to Cite

Yousif, E., Dahawi, E., Premraj, S., & Melki, W. (2024). Triple Whammy in a Patient with Portal Vein Thrombosis. Archive of Clinical Cases, 11(1), 16-18. https://doi.org/10.22551/2024.42.1101.10280