Rare case of mortality after hemorrhagic property of esthesioneuroblastoma

Todd Furr, Brandon Grodman, Jeremy Heffernan


Esthesioneuroblastoma is a tumor arising from olfactory neuroepithelium with an incidence of four per million. This case presents a rare nasal cavity neoplasm with hemorrhagic properties that may lead to significant sequelae. We present a 69-year-old male patient who presented with worsening altered mental status over the past 6-7 months. His Glasgow coma scale was a nine, showing a large mass centered at the cribriform plate with extension intracranially, sinonasal cavity, and bilateral orbits on diagnostics. Bifrontal craniotomy was performed one day after admission with resection of the tumor in the cranial fossa and intranasally, and decompression of the brainstem, frontal lobes, and third ventricle. After surgery, the patient was managed in the intensive care unit but continued to deteriorate. He was confirmed to have no meaningful brain activity and eventually deceased seven days after admission. Depending on the tumor stage, esthesioneuroblastoma can have a favorable prognosis with proper therapies. Different surgical techniques for ENB lead to the question of which therapeutic modality is the best because of the tumor's gross hemorrhagic properties. With adjunctive radiation therapy and/or chemotherapy, more research can bring light to proper surgical techniques.


esthesioneuroblastoma; olfactory neuroblastoma; postoperative hemorrhage; frontal craniotomy; Hyams grading system; modified Kadish staging system

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DOI: http://dx.doi.org/10.22551/2023.41.1004.10269

Copyright (c) 2023 Todd Furr, Brandon Grodman, Jeremy Heffernan

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