Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot

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Vol3Nr4Y2023
Published Nov 15, 2023
DOI: https://doi.org/10.22551/2023.41.1004.10264
Josef Finsterer

Abstract

Small fiber neuropathy (SFN) has not been reported after the third dose of BNT162b2 in a previously healthy vaccinee. A 44-year-old previously healthy female developed pain and sensory disturbances in varying locations after the third BNT162b2 dose. Additionally, she developed recurrent tinnitus, headaches, arthralgia, neck stiffness, and motor dysfunction. A skin biopsy five months after symptom onset revealed normal intra-epidermal nerve fiber density (IENFD) but reduced sweat gland nerve fiber density. She is intended for a first series of intravenous immunoglobulins. SARS-CoV-2 vaccinations may be complicated by SFN; the diagnosis SARS-CoV-2 vaccination SFN may be delayed; IENFD may be normal, but sweat gland nerve fiber density may document SFN; and full recovery after SFN cannot always be achieved quickly.

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Keywords

small fiber neuropathy, skin biopsy, sweat gland nerve fiber density, SARS-CoV-2 vaccination, side effect

References
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How to Cite
Finsterer, J. (2023). Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot. Archive of Clinical Cases, 10(4), Arch Clin Cases. 2023;10(4):153-156. https://doi.org/10.22551/2023.41.1004.10264
Issue
Vol. 10 No. 4 (2023)
Section
Case Reports

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How to Cite

Finsterer, J. (2023). Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot. Archive of Clinical Cases, 10(4), Arch Clin Cases. 2023;10(4):153-156. https://doi.org/10.22551/2023.41.1004.10264