Skin tumors and their viral origin

Ramona Gabriela Ursu, Luminița Smaranda Iancu

Abstract


Cutaneous tumors have risk factors, including oncogenic viruses. In this paper, the most frequent viruses known to be related to skin tumors, the available diagnostic detection assays and possible prevention and therapy are presented. The clinical utility of this report is to raise awareness to the fact that some cancer-inducing viruses may be treated with targeted therapy and some other infections can be prevented by vaccination.


Keywords


MCPyV; cutaneous HPV types; herpesviruses; skin cancer; virus-induced

Full Text:

PDF

References


Stewart BW, Wild CP. World Cancer Report 2014. Lyon, France: International Agency for Research on Cancer, 2014.

White MK, Pagano JS, Khalili K. Viruses and human cancers: a long road of discovery of molecular paradigms. Clin Microbiol Rev 2014; 27(3):463-481.

Milavetz BI, Balakrishnan L. Viral epigenetics. Methods Mol Biol 2015; 1238:569-596.

Elder DE, Massi D, Scolyer RA, Willemze R. WHO Classification of Skin Tumors, 4th Edition, IARC Press Lyon, 2018.

Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No.11. Lyon, France: International Agency for Research on Cancer; 2013. [http://gco.iarc.fr/ available at 09.23.2018].

Saini AT, Miles BA. Merkel cell carcinoma of the head and neck: pathogenesis, current and emerging treatment options. Onco Targets Ther 2015; 8:2157-2167.

Polz D, Morshed K, Stec A, Podsiadło Ł, Polz-Dacewicz M. Do polyomavirus hominis strains BK and JC play a role in oral squamous cell carcinoma? Ann Agric Environ Med 2015; 22(1):106-109.

Burger-Calderon R, Webster-Cyriaque J. Human BK Polyomavirus-The Potential for head and neck malignancy and disease. Cancers (Basel) 2015; 7(3):1244-1270.

Bussu F, Sali M, Gallus R, et al. HPV and EBV Infections in neck metastases from occult primary squamous cell carcinoma: Another Virus-related neoplastic disease in the head and neck region. Ann Surg Oncol 2015; 22(suppl 3):S979-984.

Polz-Gruszka D, Stec A, Dworzański J, Polz-Dacewicz M. EBV, HSV, CMV and HPV in laryngeal and oropharyngeal carcinoma in Polish patients. Anticancer Res 2015; 35(3):1657-1661.

Accardi R, Gheit T. Cutaneous HPV and skin cancer. Presse Med 2014; 43(12Pt2):e435-443.

Murakami I, Wada N, Nakashima J, et al. Merkel cell polyomavirus and Langerhans cell neoplasm. Cell Commun Signal 2018; 16(1):49.

Konstatinell A, Coucheron DH, Sveinbjørnsson B, Moens U. MicroRNAs as potential biomarkers in Merkel cell carcinoma. Int J Mol Sci 2018; 19(7). pii: E1873.

Kervarrec T, Samimi M, Gaboriaud P, et al. Detection of the Merkel cell polyomavirus in the neuroendocrine component of combined Merkel cell carcinoma. Virchows Arch 2018; 472(5):825-837.

Vandeven N, Lewis CW, Makarov V, et al. Merkel cell carcinoma patients presenting without a primary lesion have elevated markers of immunity, higher tumor mutation burden, and improved survival. Clin Cancer Res 2018; 24(4):963-971.

Li L, Molberg K, Cheedella N, Thibodeaux J, Hinson S, Lucas E. The diagnostic utility of Merkel cell polyomavirus immunohisto-chemistry in a fine needle aspirate of metastatic Merkel cell carcinoma of unknown primary to the pancreas. Diagn Cytopathol 2018; 46(1):67-71.

Álvarez-Argüelles ME, Melón S, Rojo S, et al. Detection and quantification of Merkel cell polyomavirus. Analysis of Merkel cell carcinoma cases from 1977 to 2015. J Med Virol 2017; 89(12):2224-2229.

Kuromi T, Matsushita M, Iwasaki T, et al. Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma. Hum Pathol 2017; 69:8-14.

Wang L, Harms PW, Palanisamy N, et al. Age and gender associations of virus positivity in Merkel cell carcinoma characterized using a novel RNA In Situ hybridization assay. Clin Cancer Res 2017; 23(18):5622-5630.

Arvia R, Sollai M, Pierucci F, Urso C, Massi D, Zakrzewska K. Droplet digital PCR (ddPCR) vs quantitative real-time PCR (qPCR) approach for detection and quantification of Merkel cell polyomavirus (MCPyV) DNA in formalin fixed paraffin embedded (FFPE) cutaneous biopsies. J Virol Methods 2017; 246:15-20.

Harms KL, Lazo de la Vega L, Hovelson DH,,et al. Molecular profiling of multiple primary Merkel cell carcinoma to distinguish genetically distinct tumors from clonally related metastases. JAMA Dermatol 2017; 153(6):505-512.

Viarisio D, Müller-Decker K, Accardi R,, et al. Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice. PLoS Pathog 2018; 14(1):e1006783.

Faust H, Andersson K, Luostarinen T, Gislefoss RE, Dillner J. Cutaneous human Papillomaviruses and squamous cell carcinoma of the skin: nested case-control study. Cancer Epidemiol Biomarkers Prev 2016; 25(4):721-724.

Arroyo Mühr LS, Hultin E, Bzhalava D, et al. Human papillomavirus type 197 is commonly present in skin tumors. Int J Cancer 2015; 136(11):2546-2555.

Shterzer N, Heyman D, Shapiro B, et al. Human papillomavirus types detected in skin warts and cancer differ in their transforming properties but commonly counteract UVB induced protective responses in human keratinocytes. Virology 2014; 468-470:647-659.

Bzhalava D, Mühr LS, Lagheden C, Ekström J, Forslund O, Dillner J, Hultin E. Deep sequencing extends the diversity of human papillomaviruses in human skin. Sci Rep 2014; 4:5807.

IARC Working Group: Evaluation of Carcinogenic Risks to Humans II. A review of human carcinogens. Part B: Biological agents (IARC monographs on the evaluation of carcinogenic risks to humans; v. 100B), IARC Press Lyon, 2009.

Ursu RG, Danciu M, Spiridon IA, et al. Role of mucosal high-risk human papillomavirus types in head and neck cancers in Romania. PLoS One 2018; 13(6):e0199663.

Bersani C, Haeggblom L, Ursu RG, et al. Overexpression of FGFR3 in HPV-positive tonsillar and base of tongue cancer is correlated to outcome. Anticancer Res 2018; 38(8):4683-4690.

Haeggblom L, Ursu RG, Mirzaie L, et al. No evidence for human papillomavirus having a causal role in salivary gland tumors. Diagn Pathol 2018; 13(1):44.

WHO: Health effects of UV radiation [http://www.who.int/uv/health/uv_health2/en/index1.html available at 09.23.2018]

Ramqvist T, Nordfors C, Dalianis T, Ragnarsson-Olding B. DNA from human polyomaviruses, TSPyV, MWPyV, HPyV6, 7 and 9 was not detected in primary mucosal melanomas. Anticancer Res 2014; 34(2):639-643.

Schrama D, Groesser L, Ugurel S, et al. Presence of human polyomavirus 6 in mutation-specific BRAF inhibitor-induced epithelial proliferations. JAMA Dermatol 2014; 150(11):1180-1186.

Purdie KJ, Proby CM, Rizvi H, et al. The role of human Papillomaviruses and Polyomaviruses in BRAF-inhibitor induced cutaneous squamous cell carcinoma and benign squamoproliferative lesions. Front Microbiol 2018; 9:1806.

Frouin E, Guillot B, Larrieux M, et al. Cutaneous epithelial tumors induced by vemurafenib involve the MAPK and Pi3KCA pathways but not HPV nor HPyV viral infection. PLoS One 2014; 9(10):e110478.

Dupin N, Deleuze J. Kaposi sarcoma and HHV-8: a model of cutaneous cancer in immunosuppressed patients. Rev Prat 2014; 64(3):311-316.

Patel A, Bishburg E, Zucker M, Tsang P, Nagarakanti S, Sabnani I. Concomitant Kaposi sarcoma and multicentric Castleman's disease in a heart transplant recipient. Heart Lung 2014; 43(6):506-509.

Le J. Oncogenic γ Herpesviruses EBV and HHV8 in Kidney Transplantation. Semin Nephrol 2016; 36(5):362-371.

Murahwa AT, Muchemwa FC, Duri K, et al. Presence of Betapapillomavirus in Kaposi sarcoma lesions. J Med Virol 2014; 86(9):1556-1559.

Murakami I, Matsushita M, Iwasaki T, et al. High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues. Infect Agent Cancer 2014; 9:15.

Binois R, Nadal M, Esteve E, et al. Cutaneous Kaposi sarcoma during treatment with superpotent topical steroids and methotrexate for bullous pemphigoid: three cases. Eur J Dermatol 2017; 27(4):369-374.

Nakao R, Sakashita A, Omoto A, et al. Primary intra-aortic Epstein-Barr virus-positive large b-cell lymphoma presenting as aortic mural thrombosis: an entity distinct from intravascular large B-cell lymphoma. Int J Surg Pathol 2017; 25(8):727-731.

Ikebe T, Sasaki H, Saburi Y, Ogata M. Bilateral psoas muscle lymphoma: an unusual presentation of EBV-positive diffuse large B-cell lymphoma of the elderly. Int J Hematol 2015; 102(5):509-510.

Montero Pérez I, Rodríguez-Pazos L, Álvarez-Pérez A, Ferreirós MM, Aliste C, Suarez-Peñaranda JM, Toribio J. Kaposi sarcoma following postmastectomy lymphedema. J Cutan Pathol 2015; 42(11):889-893.

Weiss RA. Tumour-inducing viruses. Br J Hosp Med (Lond) 2016; 77(10):565-568.

Petrosky E, Bocchini JA Jr, Hariri S. Centers for Disease Control and Prevention (CDC). Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the advisory committee on immunization practices. MMWR Morb Mortal Wkly Rep 2015; 64(11):300-304.

Shen KY, Chang LS, Leng CH, Liu SJ. Self-adjuvanting lipoimmunogens for therapeutic HPV vaccine development: potential clinical impact. Expert Rev Vaccines 2015; 14(3):383-394.

Vinzón SE, Rösl F. HPV vaccination for prevention of skin cancer. Hum Vaccin Immunother 2015; 11(2):353-357.

Tumban E, Peabody J, Peabody DS, Chackerian B. A pan-HPV vaccine based on bacteriophage PP7 VLPs displaying broadly cross-neutralizing epitopes from the HPV minor capsid protein, L2. PLoS One 2011; 6(8):e23310.

Chiocca EA, Rabkin SD. Oncolytic viruses and their application to cancer immunotherapy. Cancer Immunol Res 2014; 2(4):295-300.

Buijs PR, Verhagen JH, van Eijck CH, van den Hoogen BG. Oncolytic viruses: From bench to bedside with a focus on safety. Hum Vaccin Immunother 2015; 11(7):1573-1584.

Kohlhapp FJ, Kaufman HL. Molecular Pathways: Mechanism of action for Talimogene Laherparepvec, a new oncolytic virus Immunotherapy. Clin Cancer Res 2016; 22(5):1048-1054.

Killock D. Skin cancer: T-VEC oncolytic viral therapy shows promise in melanoma. Nat Rev Clin Oncol 2015; 12(8):438.

Andtbacka RH, Kaufman HL, Collichio F. Talimogene Laherparepvec Improves durable response rate in patients with advanced melanoma. J Clin Oncol 2015; 33(25):2780-2788.

D'Angelo SP, Russell J, Lebbé C. Efficacy and safety of first-line Avelumab treatment in patients with stage IV metastatic Merkel cell carcinoma: A preplanned interim analysis of a clinical trial. JAMA Oncol 2018; 4(9): e180077.

Colunga A, Pulliam T, Nghiem P. Merkel cell carcinoma in the age of immunotherapy: facts and hopes. Clin Cancer Res 2018; 24(9):2035-2043.

Harms PW, Patel RM, Verhaegen ME, et al. Distinct gene expression profiles of viral- and nonviral-associated Merkel cell carcinoma revealed by transcriptome analysis. J Invest Dermatol 2013; 133(4):936-945.

Nardi V, Song Y, Santamaria-Barria JA, et al. Activation of PI3K signaling in Merkel cell carcinoma. Clin Cancer Res 2012; 18(5):1227-1236.




Copyright (c) 2018 Ramona Gabriela Ursu, Luminița Smaranda Iancu

Creative Commons License
Archive of Clinical Cases is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

ISSN: 2360-6975