Clinical and pathologic features of Philadelphia chromosome-like acute lymphoblastic leukemia in a pediatric patient

Amrou Abdelkader, Horatiu Olteanu

Abstract


Philadelphia chromosome-like acute lymphoblastic leukemia (ALL), also referred to as BCR-ABL1-like ALL, is a high-risk subset of B-lymphoblastic leukemia/lymphoma that shares a significant gene expression profile with the Philadelphia-positive ALL and generally has a less favorable outcome, compared to other ALL subtypes. Because of the clinical importance of these cases, Philadelphia-like ALL has been included as a provisional entity in the 2016 WHO classification of hematolymphoid neoplasms. Here we report the clinical and pathologic findings in a patient with Philadelphia-like ALL, with emphasis on the practical diagnostic and prognostic aspects of this pediatric malignancy. 


Keywords


acute lymphoblastic leukemia; Philadelphia chromosome; BCR-ABL1; CRLF2

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References


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ISSN: 2360-6975