Clinical and pathologic features of Philadelphia chromosome-like acute lymphoblastic leukemia in a pediatric patient
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Abstract
Philadelphia chromosome-like acute lymphoblastic leukemia (ALL), also referred to as BCR-ABL1-like ALL, is a high-risk subset of B-lymphoblastic leukemia/lymphoma that shares a significant gene expression profile with the Philadelphia-positive ALL and generally has a less favorable outcome, compared to other ALL subtypes. Because of the clinical importance of these cases, Philadelphia-like ALL has been included as a provisional entity in the 2016 WHO classification of hematolymphoid neoplasms. Here we report the clinical and pathologic findings in a patient with Philadelphia-like ALL, with emphasis on the practical diagnostic and prognostic aspects of this pediatric malignancy.
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acute lymphoblastic leukemia, Philadelphia chromosome, BCR-ABL1, CRLF2
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