Cervical lymph node dissemination of a multirecurrent supratentorial ependymoma
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Abstract
Ependymomas are rare central nervous system tumors. Half the patients experience recurrence and total resection is of major importance to obtain the most chance of cure. Thus, some patients undergo several repeated resections which may occasionally be at the origin of dissemination along the neuraxis and exceptionally to extraneural sites. We report the case of a boy who presented a multiple recurrence of his supratentorial ependymoma, first at initial site and then with cervical lymph nodes metastases, highlighting the fact that multiple surgical resections may confer an added risk for hematogeneous and lymphatic dissemination. The impact of adjuvant therapies on this risk is discussed.
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ependymoma, child, surgical dissemination, extraneural metastases
2. Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumors of the central nervous system. Acta Neuropathol 2007; 114(2):97-109.
3. Massimino M, Gandola L, Giangaspero F, et al. Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma: final results of the first prospective AIEOP (Associazione Italiana di Ematologia-Oncologia Pediatrica) study. Int J Radiat Oncol Biol Phys 2004; 58(5):1336-1345.
4. Merchant TE, Li C, Xiong X, Kun LE, Boop FA, Sanford RA. Conformal radiotherapy after surgery for pediatric ependymoma: a prospective study. Lancet Oncol 2009; 10(3):258-266.
5. Khatua S, Ramaswamy V, Bouffet E. Current therapy and the evolving molecular landscape of pediatric ependymoma. Eur J Cancer 2017; 70:34-41.
6. Rickert CH. Extraneural metastases of pediatric brain tumors. Acta Neuropathol 2003; 105(4):309‑327.
7. Bademci G, Tun K, Erden E, Evliyaoglu C, Unlu A. Late dissemination of ependymoma: case report. Neurocirugia (Astur) 2007; 18(4):333-336.
8. Newton HB, Henson J, Walker RW. Extraneural metastases in ependymoma. J Neurooncol 1992; 14(2):135-142.
9. Hoffman HJ, Duffner PK. Extraneural metastases of central nervous system tumors. Cancer 1985; 56(7 Suppl):1778-1782.
10. Duffner PK, Cohen ME. Extraneural metastases in childhood brain tumors. Ann Neurol 1981; 10:261-265.
11. Chao M, Packer RJ, Myseros JS, Rood BR. Isolated extracranial recurrence of anaplastic ependymoma. Pediatr Blood Cancer 2011; 56(2):317-318.
12. Dunst J, Klinger M, Thierauf P. Ependymoma with cervical lymph node metastases. Klin Padiatr 1987; 199(1):19-21.
13. Kinoshita M, Izumoto S, Kagawa N, Hashimoto N, Maruno M, Yoshimine T. Long-term control of recurrent anaplastic ependymoma with extracranial metastasis: importance of multiple surgery and stereotactic radiosurgery procedures-case report. Neurol Med Chir 2004; 44:669-673.
14. Varan A, Sari N, Akalan N, et al. Extraneural metastasis in intracranial tumors in children: the experience of a single center. J Neurooncol 2006; 79(2):187-190.
15. Kumar P, Rastogi N, Jain M, Chhabra P. Extraneural metastases in anaplastic ependymoma. J Cancer Res Ther 2007; 3(2):102-104.
16. Hussain M, Mallucci C, Abernethy L, Godhamgaonkar V, Thorp N, Pizer B. Anaplastic ependymoma with sclerotic bone metastases. Pediatr Blood Cancer 2010; 55(6):1204-1206.
17. Fischer C, Haque SS, Huse JT, et al. Extraneural ependymoma: distant bone, lung, liver, and lymph node metastases following bevacizumab. Pediatr Blood Cancer 2013; 60(1):143-145.
18. Vanuytsel LJ, Bessell EM, Ashley SE, Bloom HJ, Brada M. Intracranial ependymoma: long-term results of a policy of surgery and radiotherapy. Int J Radiat Oncol Biol Phys 1992; 23(2):313-319.
19. Fouladi M, Helton K, Dalton J, et al. Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients. Cancer 2003; 98(10):2232-2244.
20. Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 2016; 131(6):803-820.
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